受託解析実績
2019年度~2021年度(国立研究開発法人医薬基盤・健康・栄養研究所:2019年10月1日~2021年9月1日)
アカデミア 76件 製薬企業 7件 その他企業 7件
2021年度(第1期:2021年9月2日~2022年7月31日)
アカデミア 18件 製薬企業 6件 その他企業 2件
2022年度(第2期:2022年8月1日~2023年7月31日)
アカデミア 件 製薬企業 件 その他企業 件
研究成果
2023年
- Takimoto, Y., Tsubamoto, H., Taniguchi, R., Sakata, K., Takada, Y., Adachi, J., Tomonaga, T., Ueda, T., Nakagawa, K., Narita, S., Wakimoto, Y.U., and Shibahara, H. (2023). Itraconazole Repolarizes Tumor-associated Macrophages and Suppresses Cervical Cancer Cell Growth. Anticancer Res 43, 569-580.
2022年
- Adachi, J., Kakudo, A., Takada, Y., Isoyama, J., Ikemoto, N., Abe, Y., Narumi, R., Muraoka, S., Gunji, D., Hara, Y., Katayama, R., and Tomonaga, T. (2022). Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis. Life Sci Alliance 5, e2021012025.
- Muraoka, S., Hirano, M., Isoyama, J., Nagayama, S., Tomonaga, T., and Adachi, J. (2022). Comprehensive proteomic profiling of plasma and serum phosphatidylserine-positive extracellular vesicles reveals tissue-specific proteins. iScience 25, 104012.
- Muraoka, S., Hirano, M., Isoyama, J., Ishida, M., Tomonaga, T., and Adachi, J. (2022). Automated Proteomics Sample Preparation of Phosphatidylserine-Positive Extracellular Vesicles from Human Body Fluids. ACS Omega 7, 41472-41479.
- Kasahara, K., Narumi, R., Nagayama, S., Masuda, K., Esaki, T., Obama, K., Tomonaga, T., Sakai, Y., Shimizu, Y., and Adachi, J. (2022). A large-scale targeted proteomics of plasma extracellular vesicles shows utility for prognosis prediction subtyping in colorectal cancer. Cancer Med.
- Tomiyama, E., Fujita, K., Matsuzaki, K., Narumi, R., Yamamoto, A., Uemura, T., Yamamichi, G., Koh, Y., Matsushita, M., Hayashi, Y., Hashimoto, M., Banno, E., Kato, T., Hatano, K., Kawashima, A., Uemura, M., Ukekawa, R., Takao, T., Takada, S., Uemura, H., Adachi, J., Tomonaga, T., and Nonomura, N. (2022). EphA2 on urinary extracellular vesicles as a novel biomarker for bladder cancer diagnosis and its effect on the invasiveness of bladder cancer. Br J Cancer 127, 1312-1323.
- Shirai, K., Hikita, H., Sakane, S., Narumi, R., Adachi, J., Doi, A., Tanaka, S., Tahata, Y., Yamada, R., Kodama, T., Sakamori, R., Tatsumi, T., Mita, E., Tomonaga, T., and Takehara, T. (2022). Serum amyloid P component and pro-platelet basic protein in extracellular vesicles or serum are novel markers of liver fibrosis in chronic hepatitis C patients. PLoS One 17, e0271020.
- Kajiwara, K., Chen, P.K., Abe, Y., Okuda, S., Kon, S., Adachi, J., Tomonaga, T., Fujita, Y., and Okada, M. (2022). Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition. Curr Biol 32, 3460-3476 e3466.
- Hirano, H., Abe, Y., Nojima, Y., Aoki, M., Shoji, H., Isoyama, J., Honda, K., Boku, N., Mizuguchi, K., Tomonaga, T., and Adachi, J. (2022). Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer. Sci Rep 12, 4419.
- Futami, Y., Takeda, Y., Koba, T., Narumi, R., Nojima, Y., Ito, M., Nakayama, M., Ishida, M., Yoshimura, H., Naito, Y., Fukushima, K., Takimoto, T., Edahiro, R., Matsuki, T., Nojima, S., Hirata, H., Koyama, S., Iwahori, K., Nagatomo, I., Shirai, Y., Suga, Y., Satoh, S., Futami, S., Miyake, K., Shiroyama, T., Inoue, Y., Adachi, J., Tomonaga, T., Ueda, K., and Kumanogoh, A. (2022). CD14 and lipopolysaccharide-binding protein as novel biomarkers for sarcoidosis by proteomics of serum extracellular vesicles. Int Immunol 34, 327-340.
2021年
- Iwasaki, Y.W., Sriswasdi, S., Kinugasa, Y., Adachi, J., Horikoshi, Y., Shibuya, A., Iwasaki, W., Tashiro, S., Tomonaga, T., and Siomi, H. (2021). Piwi-piRNA complexes induce stepwise changes in nuclear architecture at target loci. EMBO J, e108345.
- Kinoshita, M., Ogawa, Y., Hama, N., Ujiie, I., Hasegawa, A., Nakajima, S., Nomura, T., Adachi, J., Sato, T., Koizumi, S., et al. (2021). Neutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis. Sci Transl Med 13.
- Onidani, K., Miura, N., Sugiura, Y., Abe, Y., Watabe, Y., Kakuya, T., Mori, T., Yoshimoto, S., Adachi, J., Kiyoi, T., et al. (2021). Possible Therapeutic Strategy Involving the Purine Synthesis Pathway Regulated by ITK in Tongue Squamous Cell Carcinoma. Cancers (Basel) 13.
- Yamashita, S., Kimiwada, T., Hayashi, T., Shirane, R., and Tomonaga, T. (2021). Reconversion to ventriculoperitoneal shunt following ventriculoatrial shunt malfunction in children. Childs Nerv Syst 37, 2207-2213.
- Koba, T., Takeda, Y., Narumi, R., Shiromizu, T., Nojima, Y., Ito, M., Kuroyama, M., Futami, Y., Takimoto, T., Matsuki, T., Edahiro, R., Nojima, S., Hayama, Y., Fukushima, K., Hirata, H., Koyama, S., Iwahori, K., Nagatomo, I., Suzuki, M., Shirai, Y., Murakami, T., Nakanishi, K., Nakatani, T., Suga, Y., Miyake, K., Shiroyama, T., Kida, H., Sasaki, T., Ueda, K., Mizuguchi, K., Adachi, J., Tomonaga, T., and Kumanogoh, A. (2021). Proteomics of serum extracellular vesicles identifies a novel COPD biomarker, fibulin-3 from elastic fibres. ERJ Open Res 7.
- Saika, A., Nagatake, T., Hirata, S.I., Sawane, K., Adachi, J., Abe, Y., Isoyama, J., Morimoto, S., Node, E., Tiwari, P., Hosomi, K., Matsunaga, A., Honda, T., Tomonaga, T., Arita, M., Kabashima, K., and Kunisawa, J. (2021). omega3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor alpha. FASEB J 35, e21354.
- Sugimoto, A., Abe, Y., Watanabe, T., Hosokawa, K., Adachi, J., Tomonaga, T., Iwatani, Y., Murata, T., and Fujimuro, M. (2021). The FAT10 post-translational modification is involved in the lytic replication of Kaposi's sarcoma-associated herpesvirus. J Virol.
- Tomiyama, E., Matsuzaki, K., Fujita, K., Shiromizu, T., Narumi, R., Jingushi, K., Koh, Y., Matsushita, M., Nakano, K., Hayashi, Y., Wang, C., Ishizuya, Y., Kato, T., Hatano, K., Kawashima, A., Ujike, T., Uemura, M., Takao, T., Adachi, J., Tomonaga, T., and Nonomura, N. (2021). Proteomic analysis of urinary and tissue-exudative extracellular vesicles to discover novel bladder cancer biomarkers. Cancer Sci.
- Morii, M., Kubota, S., Hasegawa, C., Takeda, Y., Kometani, S., Enomoto, K., Suzuki, T., Yanase, S., Sato, R., Akatsu, A., Hirata, K., Honda, T., Kuga, T., Tomonaga, T., Nakayama, Y., and Yamaguchi, N. (2021). Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle. Sci Rep 11, 2616.
- Hara, Y., Zhang, B., Suzuki, A., Yamaguchi, S., Adachi, J., Tomonaga, T., Yasunaga, S., Saku, K., Aoyama, T., and Hirano, K.I. (2020). Effect of Tricaprin on Cardiac Proteome in a Mouse Model for Triglyceride Deposit Cardiomyovasculopathy. J Oleo Sci 69, 1569-1577.
- Monoe, Y., Jingushi, K., Kawase, A., Hirono, T., Hirose, R., Nakatsuji, Y., Kitae, K., Ueda, Y., Hase, H., Abe, Y., Adachi, J., Tomonaga, T., and Tsujikawa, K. (2021). Pharmacological Inhibition of miR-130 Family Suppresses Bladder Tumor Growth by Targeting Various Oncogenic Pathways via PTPN1. Int J Mol Sci 22