研究成果・新技術

研究成果

2022年

  1. Hirano, H., Abe, Y., Nojima, Y., Aoki, M., Shoji, H., Isoyama, J., Honda, K., Boku, N., Mizuguchi, K., Tomonaga, T., and Adachi, J. (2022). Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer. Sci Rep 12, 4419.
  2. Muraoka, S., Hirano, M., Isoyama, J., Nagayama, S., Tomonaga, T., and Adachi, J. (2022). Comprehensive proteomic profiling of plasma and serum phosphatidylserine-positive extracellular vesicles reveals tissue-specific proteins. iScience 25, 104012.
  3. Nagatake, T., Kishino, S., Urano, E., Murakami, H., Kitamura, N., Konishi, K., Ohno, H., Tiwari, P., Morimoto, S., Node, E., et al. (2022). Intestinal microbe-dependent omega3 lipid metabolite alphaKetoA prevents inflammatory diseases in mice and cynomolgus macaques. Mucosal Immunol.

2021年

  1. Iwasaki, Y.W., Sriswasdi, S., Kinugasa, Y., Adachi, J., Horikoshi, Y., Shibuya, A., Iwasaki, W., Tashiro, S., Tomonaga, T., and Siomi, H. (2021). Piwi-piRNA complexes induce stepwise changes in nuclear architecture at target loci. EMBO J, e108345.
  2. Kinoshita, M., Ogawa, Y., Hama, N., Ujiie, I., Hasegawa, A., Nakajima, S., Nomura, T., Adachi, J., Sato, T., Koizumi, S., et al. (2021). Neutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis. Sci Transl Med 13.
  3. Nagatake, T., Shibata, Y., Morimoto, S., Node, E., Sawane, K., Hirata, S.I., Adachi, J., Abe, Y., Isoyama, J., Saika, A., et al. (2021). 12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice. Sci Rep 11, 10426.
  4. Onidani, K., Miura, N., Sugiura, Y., Abe, Y., Watabe, Y., Kakuya, T., Mori, T., Yoshimoto, S., Adachi, J., Kiyoi, T., et al. (2021). Possible Therapeutic Strategy Involving the Purine Synthesis Pathway Regulated by ITK in Tongue Squamous Cell Carcinoma. Cancers (Basel) 13.
  5. Yamashita, S., Kimiwada, T., Hayashi, T., Shirane, R., and Tomonaga, T. (2021). Reconversion to ventriculoperitoneal shunt following ventriculoatrial shunt malfunction in children. Childs Nerv Syst 37, 2207-2213.
  6. Koba, T., Takeda, Y., Narumi, R., Shiromizu, T., Nojima, Y., Ito, M., Kuroyama, M., Futami, Y., Takimoto, T., Matsuki, T., Edahiro, R., Nojima, S., Hayama, Y., Fukushima, K., Hirata, H., Koyama, S., Iwahori, K., Nagatomo, I., Suzuki, M., Shirai, Y., Murakami, T., Nakanishi, K., Nakatani, T., Suga, Y., Miyake, K., Shiroyama, T., Kida, H., Sasaki, T., Ueda, K., Mizuguchi, K., Adachi, J., Tomonaga, T., and Kumanogoh, A. (2021). Proteomics of serum extracellular vesicles identifies a novel COPD biomarker, fibulin-3 from elastic fibres. ERJ Open Res 7.
  7. Saika, A., Nagatake, T., Hirata, S.I., Sawane, K., Adachi, J., Abe, Y., Isoyama, J., Morimoto, S., Node, E., Tiwari, P., Hosomi, K., Matsunaga, A., Honda, T., Tomonaga, T., Arita, M., Kabashima, K., and Kunisawa, J. (2021). omega3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor alpha. FASEB J 35, e21354.
  8. Sugimoto, A., Abe, Y., Watanabe, T., Hosokawa, K., Adachi, J., Tomonaga, T., Iwatani, Y., Murata, T., and Fujimuro, M. (2021). The FAT10 post-translational modification is involved in the lytic replication of Kaposi's sarcoma-associated herpesvirus. J Virol.
  9. Tomiyama, E., Matsuzaki, K., Fujita, K., Shiromizu, T., Narumi, R., Jingushi, K., Koh, Y., Matsushita, M., Nakano, K., Hayashi, Y., Wang, C., Ishizuya, Y., Kato, T., Hatano, K., Kawashima, A., Ujike, T., Uemura, M., Takao, T., Adachi, J., Tomonaga, T., and Nonomura, N. (2021). Proteomic analysis of urinary and tissue-exudative extracellular vesicles to discover novel bladder cancer biomarkers. Cancer Sci.
  10. Morii, M., Kubota, S., Hasegawa, C., Takeda, Y., Kometani, S., Enomoto, K., Suzuki, T., Yanase, S., Sato, R., Akatsu, A., Hirata, K., Honda, T., Kuga, T., Tomonaga, T., Nakayama, Y., and Yamaguchi, N. (2021). Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle. Sci Rep 11, 2616.
  11. Hara, Y., Zhang, B., Suzuki, A., Yamaguchi, S., Adachi, J., Tomonaga, T., Yasunaga, S., Saku, K., Aoyama, T., and Hirano, K.I. (2020). Effect of Tricaprin on Cardiac Proteome in a Mouse Model for Triglyceride Deposit Cardiomyovasculopathy. J Oleo Sci 69, 1569-1577.
  12. Monoe, Y., Jingushi, K., Kawase, A., Hirono, T., Hirose, R., Nakatsuji, Y., Kitae, K., Ueda, Y., Hase, H., Abe, Y., Adachi, J., Tomonaga, T., and Tsujikawa, K. (2021). Pharmacological Inhibition of miR-130 Family Suppresses Bladder Tumor Growth by Targeting Various Oncogenic Pathways via PTPN1. Int J Mol Sci 22

新技術