受託解析実績・研究成果

受託解析実績

2019年度～2021年度（国立研究開発法人医薬基盤・健康・栄養研究所：2019年10月1日～2021年9月1日）
　アカデミア　76件　製薬企業　7件　その他企業　7件　計90件

2021年度（第1期：2021年9月2日～2022年7月31日）
　アカデミア　18件　製薬企業　6件　その他企業　2件　計26件

2022年度（第2期：2022年8月1日～2023年7月31日）
　アカデミア　36件　製薬企業　8件　その他企業　10件　計54件

2023年度（第3期：2023年8月1日～2024年7月31日）
　アカデミア　60件　製薬企業　20件　その他企業　12件　計92件

研究成果

2024年

  1. Shoji, H., Hirano, H., Nojima, Y., Gunji, D., Shinkura, A., Muraoka, S., Abe, Y., Narumi, R., Nagao, C., Aoki, M., Obama, K., Honda, K., Mizuguchi, K., Tomonaga, T., Saito, Y., Yoshikawa, T., Kato, K., Boku, N., and Adachi, J. (2024). Phosphoproteomic subtyping of gastric cancer reveals dynamic transformation with chemotherapy and guides targeted cancer treatment. Cell Rep, 114774.
  2. Sakane, S., Hikita, H., Shirai, K., Sakamoto, T., Narumi, R., Adachi, J., Kakita, N., Yamada, Y., Toyoda, H., Takahashi, H., Suda, G., Kai, M., Tahata, Y., Sakamori, R., Kumazaki, S., Fukumoto, K., Myojin, Y., Murai, K., Kodama, T., Tatsumi, T., Tomonaga, T., Sakamoto, N., Morii, E., and Takehara, T. (2024). Proteomic analysis of serum extracellular vesicles reveals Fibulin-3 as a new marker predicting liver-related events in MASLD. Hepatol Commun 8.
  3. Enomoto, T., Shirai, Y., Takeda, Y., Edahiro, R., Shichino, S., Nakayama, M., Takahashi-Itoh, M., Noda, Y., Adachi, Y., Kawasaki, T., Koba, T., Futami, Y., Yaga, M., Hosono, Y., Yoshimura, H., Amiya, S., Hara, R., Yamamoto, M., Nakatsubo, D., Suga, Y., Naito, M., Masuhiro, K., Hirata, H., Iwahori, K., Nagatomo, I., Miyake, K., Koyama, S., Fukushima, K., Shiroyama, T., Naito, Y., Futami, S., Natsume-Kitatani, Y., Nojima, S., Yanagawa, M., Shintani, Y., Nogami-Itoh, M., Mizuguchi, K., Adachi, J., Tomonaga, T., Inoue, Y., and Kumanogoh, A. (2024). SFTPB in serum extracellular vesicles as a biomarker of progressive pulmonary fibrosis. JCI Insight 9
  4. Motomura, S., Yumimoto, K., Tomonaga, T., and Nakayama, K.I. (2024). CRL2(KLHDC3) and CRL1(Fbxw7) cooperatively mediate c-Myc degradation. Oncogene 43, 1917-1929.

2023年

  1. Hasegawa, N., Hongo, M., Okada, M., Kuga, T., Abe, Y., Adachi, J., Tomonaga, T., Yamaguchi, N., and Nakayama, Y. (2023). Phosphotyrosine proteomics in cells synchronized at monopolar cytokinesis reveals EphA2 as functioning in cytokinesis. Exp Cell Res 432, 113783.
  2. Takimoto, Y., Tsubamoto, H., Taniguchi, R., Sakata, K., Takada, Y., Adachi, J., Tomonaga, T., Ueda, T., Nakagawa, K., Narita, S., Wakimoto, Y.U., and Shibahara, H. (2023). Itraconazole Repolarizes Tumor-associated Macrophages and Suppresses Cervical Cancer Cell Growth. Anticancer Res 43, 569-580.
  3. Oka, M., Otani, M., Miyamoto, Y., Oshima, R., Adachi, J., Tomonaga, T., Asally, M., Nagaoka, Y., Tanaka, K., Toyoda, A., Ichikawa, K., Morishita, S., Isono, K., Koseki, H., Nakato, R., Ohkawa, Y., and Yoneda, Y. (2023). Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure. Cell Rep 42, 112884.
  4. Gunji, D., Narumi, R., Muraoka, S., Isoyama, J., Ikemoto, N., Ishida, M., Tomonaga, T., Sakai, Y., Obama, K., and Adachi, J. (2023). Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS-mutant colorectal cancer. Mol Omics.
  5. Nojima, Y., Aoki, M., Re, S., Hirano, H., Abe, Y., Narumi, R., Muraoka, S., Shoji, H., Honda, K., Tomonaga, T., Mizuguchi, K., Boku, N., and Adachi, J. (2023). Integration of pharmacoproteomic and computational approaches reveals the cellular signal transduction pathways affected by apatinib in gastric cancer cell lines. Comput Struct Biotechnol J 21, 2172-2187.
  6. Dai, T., Adachi, J., Dai, Y., Nakano, N., Yamato, M., Kikuchi, S., Usui, S., Minami, Y., Tomonaga, T., Noguchi, M., Matsubara, D., and Sakamoto, N. (2023). In-depth proteomics reveals the characteristic developmental profiles of early lung adenocarcinoma with epidermal growth factor receptor mutation. Cancer Med 12, 10755-10767.

2022年

  1. Adachi, J., Kakudo, A., Takada, Y., Isoyama, J., Ikemoto, N., Abe, Y., Narumi, R., Muraoka, S., Gunji, D., Hara, Y., Katayama, R., and Tomonaga, T. (2022). Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis. Life Sci Alliance 5, e2021012025.
  2. Muraoka, S., Hirano, M., Isoyama, J., Nagayama, S., Tomonaga, T., and Adachi, J. (2022). Comprehensive proteomic profiling of plasma and serum phosphatidylserine-positive extracellular vesicles reveals tissue-specific proteins. iScience 25, 104012.
  3. Muraoka, S., Hirano, M., Isoyama, J., Ishida, M., Tomonaga, T., and Adachi, J. (2022). Automated Proteomics Sample Preparation of Phosphatidylserine-Positive Extracellular Vesicles from Human Body Fluids. ACS Omega 7, 41472-41479.
  4. Kasahara, K., Narumi, R., Nagayama, S., Masuda, K., Esaki, T., Obama, K., Tomonaga, T., Sakai, Y., Shimizu, Y., and Adachi, J. (2022). A large-scale targeted proteomics of plasma extracellular vesicles shows utility for prognosis prediction subtyping in colorectal cancer. Cancer Med.
  5. Tomiyama, E., Fujita, K., Matsuzaki, K., Narumi, R., Yamamoto, A., Uemura, T., Yamamichi, G., Koh, Y., Matsushita, M., Hayashi, Y., Hashimoto, M., Banno, E., Kato, T., Hatano, K., Kawashima, A., Uemura, M., Ukekawa, R., Takao, T., Takada, S., Uemura, H., Adachi, J., Tomonaga, T., and Nonomura, N. (2022). EphA2 on urinary extracellular vesicles as a novel biomarker for bladder cancer diagnosis and its effect on the invasiveness of bladder cancer. Br J Cancer 127, 1312-1323.
  6. Shirai, K., Hikita, H., Sakane, S., Narumi, R., Adachi, J., Doi, A., Tanaka, S., Tahata, Y., Yamada, R., Kodama, T., Sakamori, R., Tatsumi, T., Mita, E., Tomonaga, T., and Takehara, T. (2022). Serum amyloid P component and pro-platelet basic protein in extracellular vesicles or serum are novel markers of liver fibrosis in chronic hepatitis C patients. PLoS One 17, e0271020.
  7. Kajiwara, K., Chen, P.K., Abe, Y., Okuda, S., Kon, S., Adachi, J., Tomonaga, T., Fujita, Y., and Okada, M. (2022). Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition. Curr Biol 32, 3460-3476 e3466.
  8. Hirano, H., Abe, Y., Nojima, Y., Aoki, M., Shoji, H., Isoyama, J., Honda, K., Boku, N., Mizuguchi, K., Tomonaga, T., and Adachi, J. (2022). Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer. Sci Rep 12, 4419.
  9. Futami, Y., Takeda, Y., Koba, T., Narumi, R., Nojima, Y., Ito, M., Nakayama, M., Ishida, M., Yoshimura, H., Naito, Y., Fukushima, K., Takimoto, T., Edahiro, R., Matsuki, T., Nojima, S., Hirata, H., Koyama, S., Iwahori, K., Nagatomo, I., Shirai, Y., Suga, Y., Satoh, S., Futami, S., Miyake, K., Shiroyama, T., Inoue, Y., Adachi, J., Tomonaga, T., Ueda, K., and Kumanogoh, A. (2022). CD14 and lipopolysaccharide-binding protein as novel biomarkers for sarcoidosis by proteomics of serum extracellular vesicles. Int Immunol 34, 327-340.

2021年

  1. Iwasaki, Y.W., Sriswasdi, S., Kinugasa, Y., Adachi, J., Horikoshi, Y., Shibuya, A., Iwasaki, W., Tashiro, S., Tomonaga, T., and Siomi, H. (2021). Piwi-piRNA complexes induce stepwise changes in nuclear architecture at target loci. EMBO J, e108345.
  2. Kinoshita, M., Ogawa, Y., Hama, N., Ujiie, I., Hasegawa, A., Nakajima, S., Nomura, T., Adachi, J., Sato, T., Koizumi, S., et al. (2021). Neutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis. Sci Transl Med 13.
  3. Onidani, K., Miura, N., Sugiura, Y., Abe, Y., Watabe, Y., Kakuya, T., Mori, T., Yoshimoto, S., Adachi, J., Kiyoi, T., et al. (2021). Possible Therapeutic Strategy Involving the Purine Synthesis Pathway Regulated by ITK in Tongue Squamous Cell Carcinoma. Cancers (Basel) 13.
  4. Yamashita, S., Kimiwada, T., Hayashi, T., Shirane, R., and Tomonaga, T. (2021). Reconversion to ventriculoperitoneal shunt following ventriculoatrial shunt malfunction in children. Childs Nerv Syst 37, 2207-2213.
  5. Koba, T., Takeda, Y., Narumi, R., Shiromizu, T., Nojima, Y., Ito, M., Kuroyama, M., Futami, Y., Takimoto, T., Matsuki, T., Edahiro, R., Nojima, S., Hayama, Y., Fukushima, K., Hirata, H., Koyama, S., Iwahori, K., Nagatomo, I., Suzuki, M., Shirai, Y., Murakami, T., Nakanishi, K., Nakatani, T., Suga, Y., Miyake, K., Shiroyama, T., Kida, H., Sasaki, T., Ueda, K., Mizuguchi, K., Adachi, J., Tomonaga, T., and Kumanogoh, A. (2021). Proteomics of serum extracellular vesicles identifies a novel COPD biomarker, fibulin-3 from elastic fibres. ERJ Open Res 7.
  6. Saika, A., Nagatake, T., Hirata, S.I., Sawane, K., Adachi, J., Abe, Y., Isoyama, J., Morimoto, S., Node, E., Tiwari, P., Hosomi, K., Matsunaga, A., Honda, T., Tomonaga, T., Arita, M., Kabashima, K., and Kunisawa, J. (2021). omega3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor alpha. FASEB J 35, e21354.
  7. Sugimoto, A., Abe, Y., Watanabe, T., Hosokawa, K., Adachi, J., Tomonaga, T., Iwatani, Y., Murata, T., and Fujimuro, M. (2021). The FAT10 post-translational modification is involved in the lytic replication of Kaposi's sarcoma-associated herpesvirus. J Virol.
  8. Tomiyama, E., Matsuzaki, K., Fujita, K., Shiromizu, T., Narumi, R., Jingushi, K., Koh, Y., Matsushita, M., Nakano, K., Hayashi, Y., Wang, C., Ishizuya, Y., Kato, T., Hatano, K., Kawashima, A., Ujike, T., Uemura, M., Takao, T., Adachi, J., Tomonaga, T., and Nonomura, N. (2021). Proteomic analysis of urinary and tissue-exudative extracellular vesicles to discover novel bladder cancer biomarkers. Cancer Sci.
  9. Morii, M., Kubota, S., Hasegawa, C., Takeda, Y., Kometani, S., Enomoto, K., Suzuki, T., Yanase, S., Sato, R., Akatsu, A., Hirata, K., Honda, T., Kuga, T., Tomonaga, T., Nakayama, Y., and Yamaguchi, N. (2021). Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle. Sci Rep 11, 2616.
  10. Hara, Y., Zhang, B., Suzuki, A., Yamaguchi, S., Adachi, J., Tomonaga, T., Yasunaga, S., Saku, K., Aoyama, T., and Hirano, K.I. (2020). Effect of Tricaprin on Cardiac Proteome in a Mouse Model for Triglyceride Deposit Cardiomyovasculopathy. J Oleo Sci 69, 1569-1577.
  11. Monoe, Y., Jingushi, K., Kawase, A., Hirono, T., Hirose, R., Nakatsuji, Y., Kitae, K., Ueda, Y., Hase, H., Abe, Y., Adachi, J., Tomonaga, T., and Tsujikawa, K. (2021). Pharmacological Inhibition of miR-130 Family Suppresses Bladder Tumor Growth by Targeting Various Oncogenic Pathways via PTPN1. Int J Mol Sci 22

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